LAWLESS CHAOS: LAPD tells residents to "comply" with robbers as society collapses in blue cities... escape while you still can

Blue cities in America -- run by traitorous Democrats who are desperately trying to destabilize society and bring down America -- are collapsing into lawlessness and chaos. Across NYC, Chicago, Seattle, Portland, Boston, St. Louis, Los Angeles and other blue cities, vehicle break-ins are skyrocketing, muggings are up and shoplifting is spiraling out of control to such a huge extent that many retailers (like Walgreens and CVS) are simply shutting down stores in blue cities. This week in Connecticut, thieves brazenly looted a grocery store in broad daylight, walking out with shopping carts full of grocery products (and toxic laundry detergent, weirdly), stuffing the products into vehicles with no license plates, then recklessly driving off at high speed. See the video here:

LAPD gives up on stopping crime, tells residents to "cooperate and comply" with robbers

Robberies are now so bad in Los Angeles that the LAPD is directly advising residents to "cooperate and comply" with robbers. Stunningly, even the police in LA are no longer urging people to try to stop robberies or catch the criminals carrying them out. Instead, they say "cooperate and comply" so that you can, "Be a good witness." Of course, robbers know full well that it's hard to be a good witness when you're dead. The LAPD essentially just announced a "free pass" for all criminals who seek to rob people, and they've even reminded those criminals why they might want to shoot and kill their victims in order to eliminate witnesses. This is "policing" in a liberal city. It's beyond pathetic... it's criminal. The LAPD is essentially aiding and abetting violent criminals at this point, and that stance has the full support of Democrats, of course, who think police should be defunded and that criminals should be set free. (We are not blaming the police, but rather the lunatic left-wing Marxists who give them orders.) In San Francisco, shoplifting has been legalized, so thieves simply loot retail stores in broad daylight:

Get out of blue cities while you still can

If you are crazy enough to still be living in a blue city, your window of opportunity to evacuate before the total collapse arrives is rapidly closing. It is abundantly clear that, if current trends continue, police will be forced to simply abandon large swaths of blue cities and label them, "non-enforcement zones" where criminals operate without limits. Remember the CHAZ zone in Seattle? Police evacuated, leaving the residents behind as kidnapped victims of insane, lunatic left-wing violent criminals who proclaimed ownership over six city blocks of downtown Seattle. In 2022, we're going to see something similar happening on a much larger scale, with many square miles of blue cities utterly abandoned by law enforcement. Treasonous Democrat mayors and governors, meanwhile, push unconstitutional gun restrictions in order to make sure residents cannot defend themselves against violent criminals. No police, no Second Amendment, no rule of law... you're on your own. And then when you dare defend yourself -- like Kyle Rittenhouse -- you are declared a murderer and a terrorist. Get out while you still can. Get to a pro-2A state where you can arm yourself and where you can legally deploy firearms against robbers and home invaders who mean you harm. The answer to violent crime is more guns in the hands of law-abiding citizens. States with the highest rates of gun ownership have the lowest rates of violent crime. And the cities with the worst violent crime -- Chicago comes to mind -- have the strictest gun laws that leave law-abiding citizens helpless in the face of increasingly aggressive criminals.

Food inflation will only make the criminals more desperate

The Biden regime's never-ending money printing that's pushing runaway inflation and food price increases is only making criminals more desperate. As the Biden regime prints more fiat currency, it drives low-income people to the point of poverty and homelessness. Even with rising wages, food prices are rising more than twice as fast, and the "transitory" excuse of the White House has already collapsed. Inflation is accelerating rapidly, and America is headed into a Venezuela-style hyperinflation event. The dollar is going to lose as much as 50% of its purchasing power over the next 12 months alone. Here's Gregory Mannarino (TradersChoice.net) explaining why the Fed wants inflation and continues to create it:

America in 2022: People will be freezing and starving while the dollar and the economy continue to collapse (all by design)

With the Marxist democrats in control (for the moment), the destruction of America is only accelerating. Biden is shutting down pipelines and fuel supplies. Senseless covid lockdowns are causing persistent labor shortages that are worsening the collapse of the food supply. (Food riots are coming in 2022.) And the supply chain is cratering, leading to shortages of parts and products across nearly every industry. Fertilizer plants are also being shuttered in an effort to cause global famine and mass starvation. It's all part of the Decarbonization Terraforming effort that I've documented in another article. What we are all witnessing is global-scale genocide / extermination of humanity by terrorist governments that are obviously working for some entity that isn't human. Get full details in today's Situation Update podcast here: Brighteon.com/5a54f82a-5bcf-44ec-b8ee-9c654155cc51Find a new podcast each day (plus powerful interviews) at: https://www.brighteon.com/channels/hrreport Be sure to also watch Brighteon.TV each day for live shows and broadcasts with 30+ hosts. Use Brighteon.Social for your free speech social media platform. You can also follow me on Telegram at: https://t.me/RealHealthRanger

Attorney Elicits Admission from CDC: They Crush Rights of the COVID-19 Naturally Immune without Any Proof Whatsoever

TrialSite recently showcased a California physician and whistleblower represented by attorney Aaron Siri with the law firm Siri & Glimstad LLP. Siri wrote a letter to both the Food and Drug Administration (FDA) and the Centers for Disease Control and Prevention (CDC) on behalf of their client Dr. Patricia Lee, an ICU physician and surgeon, who has had the unfortunate experience of treating many COVID-19 vaccine-injured patients. In a letter addressed to CBER Director Dr. Peter Marks and the COVID-19 Vaccine Task Force Deputy Director Dr. Tom Shimabukuro, Siri raised attention to serious claims. Specifically, the letter stated that both critical public health-related agencies are ignoring pleas from Dr. Patricia Lee to investigate the catastrophic effects of the COVID-19 vaccines on some of her patients. In the 15 years Dr. Lee has practiced medicine, she has never seen the level of adverse events she now observes with the COVID-19 vaccines. Now in his latest blog writing, Siri declares that the “CDC Admits Crushing Rights of Naturally Immune Without Proof They Transmits the Virus.”  

Attorney Aaron Siri writes that “after formal demand, the CDC concedes it does not have proof of a single instance of naturally immune individual spreading the virus.”

But how could that be? Why would the CDC implement such a “crush” on people’s civil liberties without any proof that natural immunity doesn’t work? Why has there been so much bias in favor of an all-encompassing approach despite accumulating scientific evidence of its challenges?  

Yet as Siri points out in his blog, “There are endless documents reflecting cases of vaccinated individuals becoming infected with and transmitting the virus to others.” Siri refers readers to a few studies, including the Massachusetts breakthrough infection study as well as a study in Vietnam, a French study, and the Wisconsin public health study covered by TrialSite.  

‘It gets Worse’

Problematically, the plaintiff-side counsel was able to elicit a truly troubling admission from the CDC. Their excuse for not offering “a shred of evidence of the naturally immune transmitting the virus” comes down to the simple fact that “the information is not collected.”

What? Isn’t that the public health agency’s job? What is going on in Atlanta…? And for that matter, Washington DC?

COVID-19 Infection Rate Skyrockets in America’s Most Vaccinated State: Vermont

Becker’s Healthcare, a prominent health system-focused online media reported today that Vermont is the most vaccinated state in the nation. Nearly 72% of the entire population of about 630,000 are fully vaccinated. Yet new cases of SARS-CoV-2 skyrocket, including deaths. What is going on? Why does TrialSite continue to see in the most heavily vaccinated nations and several states in the United States inordinately high rates of infection? TrialSite reports a trend observed across America and the world where the most vaccinated populations experienced acceleration in infections, including breakthrough Sars-CoV-2 cases.

The Numbers

Vermont has experienced a rapid rise in cases including many breakthrough infections and based on previous numbers, several deaths. From May through much of August of this year, new COVID-19 cases were ultra-low, pointing to the benefits of vaccination.

By July 1, 2021, only two (2) new cases were reported across the entire state and the seven-day new daily case average was four (4) cases. However, with the delta variant, case infections climbed rapidly even with a record amount of vaccination. By September 30 the seven-day daily average totaled 224, which is a massive increase from July.

Fast forward to November 10, and the seven-day daily average totals 312 in a striking—and disturbing climb in cases. Mainstream news began questioning what was occurring, and Yahoo News recently headlined an article titled, “Highly-Vaccinated Vermont has more COVID-19 than ever. Why is this happening?”  Based on data collected by USA Today, the news outlet declared, “How can a state that did so well during the first part of the pandemic—even garnering national recognition—be doing so much worse now?”

Health Commissioner Dr. Mark Levine went on the record, “There is no simple answer.”  The Vermont Health Commissioner recently shared at a news conference, “But, there are clearly factors that have come together to create the situation that we’re in now.”

Based on a modeling report by Financial Regulation Commissioner Mike Pieciak, Vermont cases have grown by 55% just in the last two weeks. Recently, the daily cases spiked above 400.

Waning Immunity

The few unvaccinated that remain are still picked on, but there aren’t enough to go around. With the 12th highest rate across all U.S. states according to Pieciak’s latest report, Dr. Levine stated recently that immunity among the first wave of vaccinated persons—those at the highest risk—is “likely waning now.”

Numerous studies including one recent national Swedish study as well as another Department of Veteran’s Affairs study suggested by month six after the second jab the Pfizer-BioNTech vaccine is less than 40% effective. By month seven one study indicated negligible benefit for BNT162b2, Pfizer’s vaccine.

Consequently, waves of booster shots are likely. But the recent data showcases the complexity of this pandemic and the limitations in the dominant narrative: that the SARS-CoV-2 pathogen can be eradicated with vaccination. While the vaccines are overall helping to reduce the probability of severe sickness, growing questions about durability will impact the prevailing pandemic fighting logic.

Unvaccinated Still More at Risk—But…

According to a piece in VTDigger, the gap between the unvaccinated and vaccinated morphs during the delta surge as the number of vaccinated Vermonters getting infected rises from 21 per 100,000 by July 31 to 138 per 100,000 as of the present.

Meanwhile, the unvaccinated experienced a rise in cases from 83 per 100,000 people to 560 per 100,000. Nonetheless, the breakthrough rate per 100,000 markedly increased in just months.

Vaccine passports transform society into a dystopian nightmare... people forced to live like fugitives

Vaccine passports turn every society into a dystopian nightmare, forcing unvaccinated people to live like fugitives, unable to buy groceries, fuel, medicine or even clothing, due to being banned from almost every retail establishment. They are also banned from banks, libraries and universities, denied access to financial services and higher education. A shocking eyewitness account of life in Lithuania -- under covid passport rules -- has now surfaced thanks to a courageous individual reporting there. The full thread is available at this link: https://threadreaderapp.com/thread/1456627584586944514.html Here are some excerpts from the thread: Banishment Increasing punishment: ever harder to get food,medicine,car fuel Segregation Undercover police raids Hate Media censorship,intimidation Here's the authoritarian future inevitably facing all countries which impose a Covid Pass regime: BANISHMENT: Lithuania is Europe's strictest Covid Pass regime. It's week 8. There's no end planned. And it's getting stricter. With no Pass, my wife and I may only enter small shops which mainly sell food, pharma, optics, or farm/pet goods. We're banned everywhere else. Without a Pass, we are banned, by law, from every clothes store. Fashion, sports, kids', punk, wedding dresses: all clothing stores ban us. Even second-hand stores must enforce the banishment. No one may buy or sell without the Pass. INCREASING PUNISHMENT: Until mid-Oct, the law allowed us to buy food and medicine in small shops. Bureaucrats decided this was too lax. Two weeks ago they imposed a new restriction on small shops: Either limit capacity to 1 shopper per 30m2 Or ban people without a Pass. The result: in many areas, there's no longer anywhere to buy food without a Pass. Supermarkets already banned us since Sept. Now small shops also ban us. So how to buy food? Online. Outdoor markets. Or travel to one of the dwindling number of shops which don't *yet* ban us. Most pharmacies chose to not ban people with no Pass. Given their small size, this decision means only one client may be inside at a time. The result: clients wait outside in the cold. Or leave without medicine. At pharmacies which require the Pass, clients enter as usual. For gas (petrol) stations, the increasing coercion has resulted in a mixed system. 2 out of 5 stations decided to completely ban people with no Pass. About 1 out of 5 still allow full access. The rest ban us from entering inside, but permit us to fill up and pay outside. SEGREGATION: In a few cases, the law doesn't banish us completely. Instead it allows us restricted service. At banks, those with the Pass receive all services. But for those without a Pass, the law only permits us "essential financial services" for a maximum of 15 minutes. POLICE STATE: Undercover plain-clothes police now raid supermarkets and shopping centers, stopping people to check their Covid Pass and ID to verify that it's a valid Pass belonging to that person. The police give press conferences about the raids: The size of the police raids is staggering. One day last week, 200 officers in plain clothes raided stores and malls. That's 2.5% of all officers in the nation. They conducted surprise investigations on 11,700 people. That's 0.4% of the entire population. In one day. Imagine: You're in a supermarket, pushing your cart through an aisle. A person in normal clothes suddenly stops you and demands to see your Covid Pass and ID. If anything is not in order, you're thrown out and face a fine of up to 5000 euros and jail of up to six years.

Governments have become terrorists, doctors have become murderers, and vaccine advocates have become death cult worshipers

The covid plandemic is a global extermination plan against humanity. This is why no government cares about human rights or human survival, since their ultimate goal is mass extermination anyway. They have abandoned the rule of law and thrown out civil rights, human rights and human dignity. Those who disagree with experimental spike protein injections are now being branded "criminals" by the CEO of Pfizer, who insists anyone who disagrees with his product should be arrested and imprisoned. The people who take the jabs are turning into vaccine zombies, exhibiting bizarre behaviors rooted in aggression and anger. They are losing higher cognitive function and devolving into "reptilian" brain stem beings, incapable of rational thought. As government bureaucrats take the shots themselves, they are also being turned into vaccine zombies with no capacity for empathy. They now see the world from a reptilian point of view -- predators and prey -- and we are the prey in their eyes. And they absolutely will not voluntarily stop until every last human being is dead or dying. The only way to save humanity is to end the government terror and the Big Pharma genocide. End the CDC, the FDA and the deadly drug cartels. Dismantle the Big Media propagandists and shut down Big Tech censorship schemes. Prosecute all those who pushed the plandemic, the vaccines, the fraudulent science and the merciless lockdowns. To free humanity, we must now fight for survival against a global death cult that no longer qualifies as human. Get full details in today's Situation Update podcast, via Brighteon.com: Brighteon.com/1d1e694c-4fd3-4181-95db-a6be989025a2Find a new podcast each day (plus powerful interviews) at: https://www.brighteon.com/channels/hrreport Be sure to also watch Brighteon.TV each day for live shows and broadcasts with 30+ hosts. And use Brighteon.Social for your free speech social media platform.

CDC Twisted the Definition of Vaccine

CDC once was a federal agency that nearly everyone respected.  That no longer is the case.  Now there are many reasons why CDC should be widely disrespected.  Its latest debacle is how it changed the definition of vaccine.

Why would the government’s key public health agency change the definition of what a vaccine is in the midst of a pandemic?  After millions of Americans have taken the shot?  And millions more are being beaten into taking it for the first time and others to get booster shots.

Here is the key point.  Long after it became widely recognized by medical experts and informed citizens that COVID vaccines clearly did not fit the official CDC vaccine definition; CDC thought the answer was not to fix what was deficient with the COVID vaccines or stop their use by most people.  Their response was to change the vaccine definition to fit the so-called vaccines.

This was done so that vaccine mandates could keep getting pushed by the government.  Of course, the COVID “vaccines” should be referred to as gene therapy products, even better than calling them experimental vaccines.

To see how corrupt this action by CDC was, it is necessary to examine the details of the vaccine definition debacle.

Prior to September 1, 2021 here is how CDC defined vaccine:

A product that stimulates a person’s immune system to produce immunity to a specific disease, protecting the person from that disease.  Vaccines are usually administered through needle injections, but can also be administered by mouth or sprayed into the nose.

This definition had been used for years and it makes sense.  No expert or sensible citizen would find fault with it.  But did it honestly apply to the COVID vaccines?

Then this is what CDC concocted:

A preparation that is used to stimulate the body’s immune response against diseases.  Vaccines are usually administered through needle injections, but some can be administered by mouth or sprayed into the nose.

Here is what CDC also said:

Immunity: Protection from an infectious disease.  If you are immune to a disease, you can be exposed to it without becoming infected.

Think about that last sentence: You can be exposed to COVID without being infected; but we know that is not true for fully vaccinated people who still get infected.

This is the key language in the original definition:

“stimulates a person’s immune system to produce immunity to a specific disease, protecting the person from that disease.”

How rational to invoke the purpose of a vaccine to stimulate an immune system to produce immunity to a specific disease that protects the recipient from that disease.  Exactly what everyone for years thought was the correct way to think about a vaccine.  People want permanent protection from the COVID infection disease.

But now CDC has taken out the language referring to getting immunity for a specific disease and getting protection from that disease.

Now, COVID vaccines do not have to directly produce immunity.  No, now they only have to stimulate the body’s immune system.

You don’t get immunity because COVID vaccines do not directly produce immunity.  They do not directly kill the COVID virus.  Vaccinated people can still have high viral loads and also transmit the virus to others.  While some individuals may get some health benefits from COVID shots, they do not necessarily protect the entire population.  This is why mandates to get everyone the shots really do not make sense from a public health perspective, that Alexander has well substantiated.

Apparently, the only logical way to understand what CDC has done is to accept the truth belatedly seen by CDC that COVID vaccines do not, in fact, produce effective immunity for COVID infection and do not provide effective protection, once vaccinated, from that infection.

Much of the public surely does not yet know what CDC has acknowledged for the COVID vaccines.  Odds are that everyone who depends on mainstream media for good information about the pandemic has not been informed about what CDC has done and its implications.

The new vaccine definition, if publicly known, would reduce public confidence in current COVID vaccines.  You don’t have to be a medical expert to see how the new definition has been created to accommodate COVID shots.

In fact, these definition changes reflect what is now known about the limitations of the COVID vaccines.

Fully vaccinated people can still get COVID disease, referred to as breakthrough infections that, contrary to what the government says, can be very serious, often requiring hospitalization and sometimes causing death, as was the case for Colin Powell.  Such serious effects have been well discussed by Kampf.   Other times, breakthrough infections greatly disrupt lives, as recently described by Madrigal, a strong proponent of COVID shots.

Moreover, the COVID vaccines are now widely known from considerable clinical evidence to lose their effectiveness typically in about six months.  And even worse, they do not provide hardly any protection against variants like the delta variant.  Same disease but from a different virus in terms of its complex genetic makeup.  So, befitting the new CDC definition the COVID shots really do not have long lasting effective immunity to the specific COVID infection caused by all variants.

Elsewhere on the CDC website is a glossary of many terms; here is what is especially relevant to the debate about COVID vaccines:

Attenuated vaccine: A vaccine in which a live microbe is weakened (attenuated) through chemical or physical processes in order to produce an immune response without causing the severe effects of the disease.  Attenuated vaccines currently licensed in the United States include measles, mumps, rubella, varicella, rotavirus, yellow fever, smallpox, and some formulations of influenza, and typhoid vaccines.

Most people would read this and find that it fits with what they think of as vaccines that have been routinely taken by most people, especially children.  Clearly, COVID vaccines do not fit this definition.  But seeing this established view of vaccines helps explain why so many people resist and reject the COVID shots.  They are so fundamentally different than long accepted and used vaccines.

The following glossary definition is especially relevant:

Active immunity: The production of antibodies against a specific disease by the immune system.  Active immunity can be acquired in two ways, either by contracting the disease or through vaccination.  Active immunity is usually permanent, meaning an individual is protected from the disease for the duration of their lives.

This CDC definition of active immunity recognizes that you can get it by contracting the disease versus through vaccination.  In other words, it recognizes what today is commonly called natural immunity achieved by once being infected by the COVID virus.  And that such immunity is likely permanent and better than vaccine immunity, as recent clinical studies substantiate.  But it also infers that active immunity obtained through vaccination is also permanent, which clearly is not the case for COVID shots, as evidenced by breakthrough infections.

To sum up, a close look at what CDC has done lately reinforces the thinking of millions of people who have reservations and concerns about getting COVID genetic therapy shots that pose myriad adverse impacts and sometimes death.  There is a rational basis for thinking that the limited benefits of those shots do not adequately offset their risks.  This is true for the vast majority of healthy people, especially children, who have extremely low risk from COVID infection for serious illness, hospitalization or death.

How interesting it would be, in the context of informed consent, if people were shown the original and new vaccine definitions as a means to stimulate productive discussion with medical providers of COVID shots.

Dr. Joel S. Hirschhorn, author of Pandemic Blunder and many articles, podcasts and radio shows on the pandemic, worked on health issues for decades. As a full professor at the University of Wisconsin, Madison, he directed a medical research program between the colleges of engineering and medicine.  As a senior official at the Congressional Office of Technology Assessment and the National Governors Association, he directed major studies on health-related subjects; he testified at over 50 US Senate and House hearings and authored hundreds of articles and op-ed articles in major newspapers.  He has served as an executive volunteer at a major hospital for more than 10 years.  He is a member of the Association of American Physicians and Surgeons, and America’s Frontline Doctors.

Bill Gates Acknowledges COVID-19 Vaccines Not Stopping Viral Transmission: Fundamental Premises Questioned?

Recently a nonprofit group called Policy Exchange facilitated a filmed interaction with Jeremy Hunt and Bill Gates. A British politician, Hunt has served the UK’s government as chair of the Health and Social Care Select Committee since 2020. Of course, Gates, one of the world’s wealthiest people, has become a high profile figure in the world of philanthropy and vaccine development. During the recent exchange the Microsoft founder made some eyebrow raising statements about the current COVID-19 vaccines on the market. Specifically in addition to several views on topics from the pandemic to climate change, Gates declared “We didn’t have vaccines that block transmission” which seemingly refutes previous comments by the billionaire. Gates got even more frank declaring “We got vaccines that help you with your health, but they only slightly reduce transmission.”

TrialSite provides a link to the interview. A number of websites such as Rebel News also featured the interview Bill Gates admits COVID-19 vaccines don’t stop viral transmission – Rebel News suggesting that one of the world’s preeminent public health investors and prominent supporters of the current COVID-19 vaccine strategy admits to the failure of the vaccine industry. 

No vaccine is full proof, and the COVID-19 vaccines are no exception. Still early-stage life science-based products, the vaccines will become better over time.  A historical milestone during the COVID-19 pandemic, powerful new vaccines were produced in less than a year—simply unprecedented.  Moreover, significant evidence supports part of the government narrative—that the vaccines have prevented millions of more severe COVID-19 cases while preventing death so TrialSite doesn’t agree that Gates’ comments are an admission of outright failure.

However, where the Gates comments raise controversy is when considering the underlying premise behind mass vaccination, including mandates for adults in businesses with over 100 employees or aggressive pushes by the federal government in the United States to get all children vaccinated.

From this point of view children are “reservoirs” for the pathogen and that vaccination could stop the spread of the disease via this reservoir.  But numerous studies now indicate durability challenges including waning effectiveness and considerable viral transmission—from vaccinated persons.  

The vaccine products represent historically notable progress in vaccination development with the first product releases comparable to the version 1.0 analogy. While on the one hand they represent an amazing set of accomplishments, on the other hand it might be too early to declare they are designed to end the pandemic.

TrialSite, an apolitical place, shares the video interview so the community members can determine for themselves the Gates comments and associated implications.  TrialSite has discussed that the vaccines can help save lives, particularly the elderly and people with higher risk profiles.  As Bill Gates declared in the interaction with Hunt the vaccines are on the one hand providing protection against more serious forms of COVID-19. However, on the other hand accumulating data points indicate higher risks for some serious adverse events than are disclosed.   Importantly as well due to durability challenges viral transmission increases in the vaccinated just months after the administration of the second dose.

Gates Departs from Pack?

A fundamental premise for the mass vaccination programs have been that the vaccines would stop viral transmission. However, that isn’t the case as study after study reveals durability challenges with the vaccines.  These are new products which will improve over time but it could very well be that no vaccine can simply stop COVID-19.

Is the recent admission by Gates as to limitations of the vaccines indicative of changes to come in his approach to funding novel vaccines?  

What is the Policy Exchange?

The London-based Policy Exchange is according to Wikipedia a British center-right-wing think tank which can inform government policy in the UK. The group was formed in 2002 as an independent, non-partisan educational charity with a mission to promote new policy ideas for improved outcomes—e.g. better public services while bolstering society.

COVID-19: A Mucosal Disease

The Influenza Model: Pandemic Experience.

Covid-19 is an RNA viral infection of airways’ mucosa with mechanisms and clinical characteristics similar to those of influenza and both can occur in pandemics. Currently it is Covid-19 that has our attention, with 250 million documented infections and in excess of 5 million deaths. In 1918-1919 Spanish influenza infected 500 million people (one third of the world), with 10% mortality (compared to Covid with 3% infected and 2% mortality). Spanish influenza swept the world in three waves over two years. The middle and most lethal wave was driven by a mutant, involving haemagglutinin and RNA polymerase, identified from naturally stored virus (1).

How is this relevant to Covid-19?

After 1919, H1N1 became the “driver” of influenza during the following century. Within 3 years H1N1 had mutated into “seasonal” flu with a mortality less than 0.1%. The question is “will this happen with SARS-CoV-2?”  We do not know but antigen drift and herd immunity are probable connected variables likely to determine any switch from pandemic to endemic disease. Differences in population exposure and the impact of vaccination on mutant selection remain unknowns (2). Currently 51% of the world’s population have had at least one “jab”, but in low-income countries, this figure is only 4%. Mortality appears higher in those countries with high vaccination rates (3). Vaccine-induced immunity is less durable and more restricted than natural immunity, possibly leading to a greater chance of mutant selection (4). Epidemiologists in Sweden point to the near absence of a third wave (less than 1000 cases and 10 deaths per day for 5 months) and attribute this shift towards “seasonal flu status”, to less lockdowns and less restrictions, leading to higher natural immunity (5). Also, vaccination in Sweden was delayed, with less than one third vaccinated by mid 2021.

In summary, populations least “protected” by lockdowns and vaccination, may most closely resemble the 1918-1919 influenza pandemic transition to “seasonal” infection with a low mortality.

• The Influenza Model: Infection of a mucosal compartment.

 “Textbook assurances that T-cell and B-cell memory priming give lasting protection—–were looking thin”: this conclusion from a recent review (6) on booster shots should not have surprised.It is exactly what is to be expected of a systemic vaccine, given for a viral infection of the respiratory tract and is amply illustrated by influenza vaccination. Attenuation of systemic and mucosal immunity follows the “rules” of mucosal immunology. Four eminent mucosal immunologists identified mucosal immunology as “Neglected but Critical” to the understanding of Covid-19 infection (7). They traced the sIgA2 antibody response from inductive sites within the nasopharynx-associated lymphoid tissue (NALT) of Waldeyer’s Ring, to the homing of B-lymphocytes to mucosal sites (IgA) and systemic lymphoid tissue (IgG) determined by receptors, specific for respective target tissues. Important additions to this “classic” review include:

• Similar circuitry for T cells – Th17 cells from aggregated lymphoid tissue recruit neutrophils, drive protective cytokines and control innate immunity (8).

• Complicated cell interactions at mucosal surfaces including antigen & functionally specific dendritic cell populations, activate both CD4+ CD25+ and CD8+ T-reg cells which powerfully supress both mucosal and systemic immune responses (9).

• A “common mucosal system” exists based on cell-homing characteristics: NARES is important within the nasopharynx, but Peyer’s patches in the gut populate the bronchus mucosa with T- and B-cells (10).

• Viral interaction with the microbiome influences infection outcome (11).

Recent data from study of nasal secretions in Covid-19 (11) has confirmed:

• the compartmental distribution of antibody and cytokine responses.

• linkage of impaired innate immunity with clinical Covid.

• the importance of the microbiome.

Differences between Covid-19 and seasonal influenza such as a twenty-fold greater mortality from Covid-19, are due, in part, to SARS-CoV-2 receptors extending to within the alveoli (favouring alveolitis) (12) and the toxic effect of the Spike protein on micro-vasculature (13).

• Understanding Covid-19 Vaccine limitations.

• Covid-19 and influenza vaccines reduce the incidence of severe disease for 6-9 months, with little effect on asymptomatic infection (due to control of alveolitis by IgG antibody but minimal impact on the mucosal compartment (14,15). Corona and influenza viruses in the community cause recurrent mucosal infections and downregulation of systemic immunity by T-reg cells (16). Unregulated synthesis of spike protein following genetic vaccines means unpredictable stimulus-response dynamics, including potential for high-dose tolerance in some subjects (17). Attenuation of antibody responses (18), and the blunted anamnestic antibody responses following “second jabs” (19) reflect down regulation. Injected vaccines have little impact on mucosal immunity, mucosal infection and viral transmission. (20).

• Increased Covid infections in UK and Sweden in older vaccinated subjects (21), may reflect enhancing antibody outlasting protective antibody as documented with infections such as Dengue (22).

• “Booster Shots”. Spacing may be critical as frequent vaccination with the same antigen may cause net immune suppression (23). Given that there is uncontrolled antigen dose with genetic vaccines, annual vaccination with antigen-based vaccines, as used in influenza, is a more logical way forward (and avoids unacceptable adverse event profiles, seen in current reports). Combining vaccines with drugs to prevent or treat early disease, offers an attractive option.

• Immune-mediated cell toxicity. The high incidence of reports ofpost-vaccination adverse events, including death (24), may involve antibody or T-cell induced toxicity directed against surface expressed spike protein (25). “Boosters” loom as a particular risk. Ongoing vaccine strategy must consider such issues.

• Mucosal Immune senescence. Generation of adaptive immune mechanisms and linked threshold innate immunity required to control virus-initiated mucosal damage, is less efficient in those aged over 65, especially in men (26). Delayed immunity in those over 65, causes an increase in viral load, more severe disease and delayed antibody response following vaccination (27).

• Conclusion. Covid-19 is a mucosal infection influenced by the rules of mucosal immunology. Influenza, its vaccine and natural history, is a useful model enabling an understanding and prediction of Covid-19 behaviour. The host-virus relationship within the airways drives the course of Covid: locally it restricts virus extension into the gas exchange apparatus. The balance between T- and B- cell immunity and T-reg cells, generated within the mucosa and their interaction with viral antigen within alveoli, influences disease outcome, vaccine efficacy and adverse events. While genetic vaccines have played a role in the pandemic, they are “experimental”, with unanswered questions including a potential impact on the transition to “seasonal” infections. Review within the frame of mucosal immunology is an opportunity to define a vaccine strategy best suited to control of Covid-19. The strategic rejection of safe, inexpensive and effective re-purposed drugs to help confine infection to within the mucosal compartment, to protect a vaccine of limited value and pharmaceutical company interests, will be noted in history as a monumental error of the pandemic (28).